Showing CypComp Card for CC02026: Propranolol (CypBoM Training Set)

Record Information
Version1.0
Creation Date2019-07-14 16:36:23 UTC
Last Updated2019-10-01 21:41:17 UTC
CypComp IDCC02026
Compound Information
NamePropranolol
Structure ImageAqhhhdlhhxjyjd cqszacivsa n
InChIKeyAQHHHDLHHXJYJD-CQSZACIVSA-N
PubChem ID21138
CypCompound Information
SetCypBoM Training Set
Bonds of Metabolism (BoMs)
CYP1A2CYP2A6CYP2B6CYP2C8CYP2C9CYP2C19CYP2D6CYP2E1CYP3A4
  • <10,4;Cleavage;R1>
  • <10,H;Oxidation;R1>
  • <14,H;Hydroxylation;R2>
  • <15,H;Hydroxylation;R3>
  • Not Available
  • Not Available
  • Not Available
  • Not Available
  • Not Available
  • <10,4;Cleavage;R1>
  • <10,H;Oxidation;R1>
  • <14,H;Hydroxylation;R2>
  • <15,H;Hydroxylation;R3>
  • Not Available
  • Not Available
References
  1. Rowland K, Ellis SW, Lennard MS, Tucker GT: Variable contribution of CYP2D6 to the N-dealkylation of S-(-)-propranolol by human liver microsomes. Br J Clin Pharmacol. 1996 Sep;42(3):390-3. doi: 10.1046/j.1365-2125.1996.43116.x. [PubMed:8877032 ]
  2. Ching MS, Bichara N, Blake CL, Ghabrial H, Tukey RH, Smallwood RA: Propranolol 4- and 5-hydroxylation and N-desisopropylation by cloned human cytochrome P4501A1 and P4501A2. Drug Metab Dispos. 1996 Jun;24(6):692-4. [PubMed:8781788 ]
  3. Mankowski DC: The role of CYP2C19 in the metabolism of (+/-) bufuralol, the prototypic substrate of CYP2D6. Drug Metab Dispos. 1999 Sep;27(9):1024-8. [PubMed:10460802 ]
  4. Yoshimoto K, Echizen H, Chiba K, Tani M, Ishizaki T: Identification of human CYP isoforms involved in the metabolism of propranolol enantiomers--N-desisopropylation is mediated mainly by CYP1A2. Br J Clin Pharmacol. 1995 Apr;39(4):421-31. doi: 10.1111/j.1365-2125.1995.tb04472.x. [PubMed:7640150 ]
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