Showing CypComp Card for CC02036: Ropivacaine (CypBoM Training Set)

Record Information
Version1.0
Creation Date2019-07-14 16:36:27 UTC
Last Updated2019-10-01 21:41:18 UTC
CypComp IDCC02036
Compound Information
NameRopivacaine
Structure ImageZkmnummkybvtfn hnnxbmfysa n
InChIKeyZKMNUMMKYBVTFN-HNNXBMFYSA-N
PubChem ID175805
CypCompound Information
SetCypBoM Training Set
Bonds of Metabolism (BoMs)
CYP1A2CYP2A6CYP2B6CYP2C8CYP2C9CYP2C19CYP2D6CYP2E1CYP3A4
  • <4,H;Hydroxylation;R1>
  • <6,H;Hydroxylation;R2>
  • Not Available
  • <5,H;Hydroxylation;R1>
  • Not Available
  • Not Available
  • Not Available
  • <5,H;Hydroxylation;R1>
  • Not Available
  • <18,13;Cleavage;R1>
  • <18,H;Oxidation;R1>
  • <5,H;Hydroxylation;R2>
  • <8,H;Hydroxylation;R3>
  • <9,H;Hydroxylation;R4>
References
  1. Ekstrom G, Gunnarsson UB: Ropivacaine, a new amide-type local anesthetic agent, is metabolized by cytochromes P450 1A and 3A in human liver microsomes. Drug Metab Dispos. 1996 Sep;24(9):955-61. [PubMed:8886604 ]
  2. Oda Y, Furuichi K, Tanaka K, Hiroi T, Imaoka S, Asada A, Fujimori M, Funae Y: Metabolism of a new local anesthetic, ropivacaine, by human hepatic cytochrome P450. Anesthesiology. 1995 Jan;82(1):214-20. doi: 10.1097/00000542-199501000-00026. [PubMed:7832304 ]
Download FileCC02036.sdf