Showing CypComp Card for CC02044: Tamoxifen (CypBoM Training Set)

Record Information
Version1.0
Creation Date2019-07-14 16:36:29 UTC
Last Updated2019-10-01 21:41:19 UTC
CypComp IDCC02044
Compound Information
NameTamoxifen
Structure ImageNkanxqfjjicgdu qplcgjkrsa n
InChIKeyNKANXQFJJICGDU-QPLCGJKRSA-N
PubChem ID2733526
CypCompound Information
SetCypBoM Training Set
Bonds of Metabolism (BoMs)
CYP1A2CYP2A6CYP2B6CYP2C8CYP2C9CYP2C19CYP2D6CYP2E1CYP3A4
  • <27,26;Cleavage;R1>
  • <27,H;Oxidation;R1>
  • <28,26;Cleavage;R2>
  • <28,H;Oxidation;R2>
  • Not Available
  • <22,H;Hydroxylation;R1>
  • <21,H;Hydroxylation;R2>
  • <27,26;Cleavage;R1>
  • <27,H;Oxidation;R1>
  • <28,26;Cleavage;R2>
  • <28,H;Oxidation;R2>
  • <27,26;Cleavage;R1>
  • <27,H;Oxidation;R1>
  • <28,26;Cleavage;R2>
  • <28,H;Oxidation;R2>
  • <27,26;Cleavage;R1>
  • <27,H;Oxidation;R1>
  • <28,26;Cleavage;R2>
  • <28,H;Oxidation;R2>
  • <21,H;Hydroxylation;R3>
  • <27,26;Cleavage;R1>
  • <27,H;Oxidation;R1>
  • <28,26;Cleavage;R2>
  • <28,H;Oxidation;R2>
  • <21,H;Hydroxylation;R3>
  • <22,H;Hydroxylation;R4>
  • <6,H;Hydroxylation;R5>
  • <27,26;Cleavage;R1>
  • <27,H;Oxidation;R1>
  • <28,26;Cleavage;R2>
  • <28,H;Oxidation;R2>
  • <21,H;Hydroxylation;R3>
  • <27,26;Cleavage;R1>
  • <27,H;Oxidation;R1>
  • <28,26;Cleavage;R2>
  • <28,H;Oxidation;R2>
  • <21,H;Hydroxylation;R3>
  • <22,H;Hydroxylation;R4>
  • <6,H;Hydroxylation;R5>
References
  1. Desta Z, Ward BA, Soukhova NV, Flockhart DA: Comprehensive evaluation of tamoxifen sequential biotransformation by the human cytochrome P450 system in vitro: prominent roles for CYP3A and CYP2D6. J Pharmacol Exp Ther. 2004 Sep;310(3):1062-75. doi: 10.1124/jpet.104.065607. Epub 2004 May 24. [PubMed:15159443 ]
  2. Crewe HK, Notley LM, Wunsch RM, Lennard MS, Gillam EM: Metabolism of tamoxifen by recombinant human cytochrome P450 enzymes: formation of the 4-hydroxy, 4'-hydroxy and N-desmethyl metabolites and isomerization of trans-4-hydroxytamoxifen. Drug Metab Dispos. 2002 Aug;30(8):869-74. doi: 10.1124/dmd.30.8.869. [PubMed:12124303 ]
  3. Styles JA, Davies A, Lim CK, De Matteis F, Stanley LA, White IN, Yuan ZX, Smith LL: Genotoxicity of tamoxifen, tamoxifen epoxide and toremifene in human lymphoblastoid cells containing human cytochrome P450s. Carcinogenesis. 1994 Jan;15(1):5-9. doi: 10.1093/carcin/15.1.5. [PubMed:8293548 ]
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