Showing CypComp Card for CC02050: Terbinafine (CypBoM Training Set)

Record Information
Version1.0
Creation Date2019-07-14 16:36:32 UTC
Last Updated2019-10-01 21:41:20 UTC
CypComp IDCC02050
Compound Information
NameTerbinafine
Structure ImageDomxuemwdbaqbq wevvvxlnsa n
InChIKeyDOMXUEMWDBAQBQ-WEVVVXLNSA-N
PubChem ID1549008
CypCompound Information
SetCypBoM Training Set
Bonds of Metabolism (BoMs)
CYP1A2CYP2A6CYP2B6CYP2C8CYP2C9CYP2C19CYP2D6CYP2E1CYP3A4
  • <1,2;EpOxidation;R1>
  • <7,8;EpOxidation;R2>
  • <20,H;Hydroxylation;R3>
  • <21,H;Hydroxylation;R4>
  • <22,H;Hydroxylation;R5>
  • <13,12;Cleavage;R6>
  • <13,H;Oxidation;R6>
  • <11,12;Cleavage;R7>
  • <11,H;Oxidation;R7>
  • Not Available
  • <20,H;Hydroxylation;R1>
  • <21,H;Hydroxylation;R2>
  • <22,H;Hydroxylation;R3>
  • <13,12;Cleavage;R4>
  • <13,H;Oxidation;R4>
  • <20,H;Hydroxylation;R1>
  • <21,H;Hydroxylation;R2>
  • <22,H;Hydroxylation;R3>
  • <13,12;Cleavage;R4>
  • <13,H;Oxidation;R4>
  • <11,12;Cleavage;R5>
  • <11,H;Oxidation;R5>
  • <1,2;EpOxidation;R1>
  • <7,8;EpOxidation;R2>
  • <20,H;Hydroxylation;R3>
  • <21,H;Hydroxylation;R4>
  • <22,H;Hydroxylation;R5>
  • <13,12;Cleavage;R6>
  • <13,H;Oxidation;R6>
  • <11,12;Cleavage;R7>
  • <11,H;Oxidation;R7>
  • <20,H;Hydroxylation;R1>
  • <21,H;Hydroxylation;R2>
  • <22,H;Hydroxylation;R3>
  • <13,12;Cleavage;R4>
  • <13,H;Oxidation;R4>
  • <11,12;Cleavage;R5>
  • <11,H;Oxidation;R5>
  • Not Available
  • Not Available
  • <13,12;Cleavage;R1>
  • <13,H;Oxidation;R1>
  • <11,12;Cleavage;R2>
  • <11,H;Oxidation;R2>
References
  1. Vickers AE, Sinclair JR, Zollinger M, Heitz F, Glanzel U, Johanson L, Fischer V: Multiple cytochrome P-450s involved in the metabolism of terbinafine suggest a limited potential for drug-drug interactions. Drug Metab Dispos. 1999 Sep;27(9):1029-38. [PubMed:10460803 ]
Download FileCC02050.sdf