Showing CypComp Card for CC02063: Troglitazone (CypBoM Training Set)

Record Information
Version1.0
Creation Date2019-07-14 16:36:36 UTC
Last Updated2019-10-01 21:41:21 UTC
CypComp IDCC02063
Compound Information
NameTroglitazone
Structure ImageGxphkuhsujuwkp cyfredjksa n
InChIKeyGXPHKUHSUJUWKP-CYFREDJKSA-N
PubChem ID6518172
CypCompound Information
SetCypBoM Training Set
Bonds of Metabolism (BoMs)
CYP1A2CYP2A6CYP2B6CYP2C8CYP2C9CYP2C19CYP2D6CYP2E1CYP3A4
  • <11,16;Oxidation;R1>
  • <11,6;Reduction;R1>
  • <6,2;Oxidation;R1>
  • <2,1;Reduction;R1>
  • <1,4;Reduction;R1>
  • <4,8;Oxidation;R1>
  • <8,11;Reduction;R1>
  • <1,3;Cleavage;R1>
  • <11,16;Oxidation;R1>
  • <11,6;Reduction;R1>
  • <6,2;Oxidation;R1>
  • <2,1;Reduction;R1>
  • <1,4;Reduction;R1>
  • <4,8;Oxidation;R1>
  • <8,11;Reduction;R1>
  • <1,3;Cleavage;R1>
  • <11,16;Oxidation;R1>
  • <11,6;Reduction;R1>
  • <6,2;Oxidation;R1>
  • <2,1;Reduction;R1>
  • <1,4;Reduction;R1>
  • <4,8;Oxidation;R1>
  • <8,11;Reduction;R1>
  • <1,3;Cleavage;R1>
  • <11,16;Oxidation;R1>
  • <11,6;Reduction;R1>
  • <6,2;Oxidation;R1>
  • <2,1;Reduction;R1>
  • <1,4;Reduction;R1>
  • <4,8;Oxidation;R1>
  • <8,11;Reduction;R1>
  • <1,3;Cleavage;R1>
  • <11,16;Oxidation;R1>
  • <11,6;Reduction;R1>
  • <6,2;Oxidation;R1>
  • <2,1;Reduction;R1>
  • <1,4;Reduction;R1>
  • <4,8;Oxidation;R1>
  • <8,11;Reduction;R1>
  • <1,3;Cleavage;R1>
  • <11,16;Oxidation;R1>
  • <11,6;Reduction;R1>
  • <6,2;Oxidation;R1>
  • <2,1;Reduction;R1>
  • <1,4;Reduction;R1>
  • <4,8;Oxidation;R1>
  • <8,11;Reduction;R1>
  • <1,3;Cleavage;R1>
  • <11,16;Oxidation;R1>
  • <11,6;Reduction;R1>
  • <6,2;Oxidation;R1>
  • <2,1;Reduction;R1>
  • <1,4;Reduction;R1>
  • <4,8;Oxidation;R1>
  • <8,11;Reduction;R1>
  • <1,3;Cleavage;R1>
  • <11,16;Oxidation;R1>
  • <11,6;Reduction;R1>
  • <6,2;Oxidation;R1>
  • <2,1;Reduction;R1>
  • <1,4;Reduction;R1>
  • <4,8;Oxidation;R1>
  • <8,11;Reduction;R1>
  • <1,3;Cleavage;R1>
  • <11,16;Oxidation;R1>
  • <11,6;Reduction;R1>
  • <6,2;Oxidation;R1>
  • <2,1;Reduction;R1>
  • <1,4;Reduction;R1>
  • <4,8;Oxidation;R1>
  • <8,11;Reduction;R1>
  • <1,3;Cleavage;R1>
References
  1. Tang W: Drug metabolite profiling and elucidation of drug-induced hepatotoxicity. Expert Opin Drug Metab Toxicol. 2007 Jun;3(3):407-20. doi: 10.1517/17425255.3.3.407. [PubMed:17539747 ]
  2. Okada R, Maeda K, Nishiyama T, Aoyama S, Tozuka Z, Hiratsuka A, Ikeda T, Kusuhara H, Sugiyama Y: Involvement of different human glutathione transferase isoforms in the glutathione conjugation of reactive metabolites of troglitazone. Drug Metab Dispos. 2011 Dec;39(12):2290-7. doi: 10.1124/dmd.111.040469. Epub 2011 Sep 13. [PubMed:21914835 ]
  3. Yokoi T: Troglitazone. Handb Exp Pharmacol. 2010;(196):419-35. doi: 10.1007/978-3-642-00663-0_14. [PubMed:20020270 ]
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