Showing CypComp Card for CC02065: Verapamil (CypBoM Training Set)

Record Information
Version1.0
Creation Date2019-07-14 16:36:38 UTC
Last Updated2019-10-01 21:41:22 UTC
CypComp IDCC02065
Compound Information
NameVerapamil
Structure ImageSgtnsnpwrioybx hhhxnrcgsa n
InChIKeySGTNSNPWRIOYBX-HHHXNRCGSA-N
PubChem ID65808
CypCompound Information
SetCypBoM Training Set
Bonds of Metabolism (BoMs)
CYP1A2CYP2A6CYP2B6CYP2C8CYP2C9CYP2C19CYP2D6CYP2E1CYP3A4
  • <25,24;Cleavage;R1>
  • <25,H;Oxidation;R1>
  • <13,24;Cleavage;R2>
  • <13,H;Oxidation;R2>
  • Not Available
  • Not Available
  • <25,24;Cleavage;R1>
  • <25,H;Oxidation;R1>
  • <13,24;Cleavage;R2>
  • <13,H;Oxidation;R2>
  • <32,8;Cleavage;R3>
  • <32,H;Oxidation;R3>
  • <31,7;Cleavage;R4>
  • <31,H;Oxidation;R4>
  • <25,24;Cleavage;R1>
  • <25,H;Oxidation;R1>
  • <13,24;Cleavage;R2>
  • <13,H;Oxidation;R2>
  • Not Available
  • Not Available
  • <25,24;Cleavage;R1>
  • <25,H;Oxidation;R1>
  • <13,24;Cleavage;R2>
  • <13,H;Oxidation;R2>
  • <32,8;Cleavage;R3>
  • <32,H;Oxidation;R3>
  • <25,24;Cleavage;R1>
  • <25,H;Oxidation;R1>
  • <13,24;Cleavage;R2>
  • <13,H;Oxidation;R2>
  • <32,8;Cleavage;R3>
  • <32,H;Oxidation;R3>
References
  1. Busse D, Cosme J, Beaune P, Kroemer HK, Eichelbaum M: Cytochromes of the P450 2C subfamily are the major enzymes involved in the O-demethylation of verapamil in humans. Naunyn Schmiedebergs Arch Pharmacol. 1995 Dec;353(1):116-21. [PubMed:8750925 ]
  2. Kroemer HK, Gautier JC, Beaune P, Henderson C, Wolf CR, Eichelbaum M: Identification of P450 enzymes involved in metabolism of verapamil in humans. Naunyn Schmiedebergs Arch Pharmacol. 1993 Sep;348(3):332-7. [PubMed:8232610 ]
  3. Tracy TS, Korzekwa KR, Gonzalez FJ, Wainer IW: Cytochrome P450 isoforms involved in metabolism of the enantiomers of verapamil and norverapamil. Br J Clin Pharmacol. 1999 May;47(5):545-52. doi: 10.1046/j.1365-2125.1999.00923.x. [PubMed:10336579 ]
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