Bonds of Metabolism (BoMs) | CYP1A2 | CYP2A6 | CYP2B6 | CYP2C8 | CYP2C9 | CYP2C19 | CYP2D6 | CYP2E1 | CYP3A4 | - <8,9;Reduction;R1>
- <28,27;Cleavage;R2>
- <28,H;Oxidation;R2>
- <26,25;Cleavage;R3>
- <26,H;Oxidation;R3>
| | | | | | | | - <8,9;Reduction;R1>
- <28,27;Cleavage;R2>
- <28,H;Oxidation;R2>
- <26,25;Cleavage;R3>
- <26,H;Oxidation;R3>
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References | - Evanchik MJ, Allen D, Yoburn JC, Silverman JA, Hoch U: Metabolism of (+)-1,4-dihydro-7-(trans-3-methoxy-4-methylamino-1-pyrrolidinyl)-4-oxo-1-(2-thiaz olyl)-1,8-naphthyridine-3-carboxylic acid (voreloxin; formerly SNS-595), a novel replication-dependent DNA-damaging agent. Drug Metab Dispos. 2009 Mar;37(3):594-601. doi: 10.1124/dmd.108.023432. Epub 2008 Dec 12. [PubMed:19074528 ]
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