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Record Information
Version1.0
Creation Date2019-07-14 16:36:40 UTC
Last Updated2019-10-01 21:41:22 UTC
CypComp IDCC02068
Compound Information
NameZileuton
Structure ImageMwlsowxnzpkenc zetcqymhsa n
InChIKeyMWLSOWXNZPKENC-ZETCQYMHSA-N
PubChem ID10220327
CypCompound Information
SetCypBoM Training Set
Bonds of Metabolism (BoMs)
CYP1A2CYP2A6CYP2B6CYP2C8CYP2C9CYP2C19CYP2D6CYP2E1CYP3A4
  • <11,H;Hydroxylation;R1>
  • <12,H;Hydroxylation;R2>
  • <15,H;Hydroxylation;R3>
  • <16,H;Hydroxylation;R4>
  • Not Available
  • Not Available
  • Not Available
  • <11,H;Hydroxylation;R1>
  • <12,H;Hydroxylation;R2>
  • <15,H;Hydroxylation;R3>
  • <16,H;Hydroxylation;R4>
  • Not Available
  • Not Available
  • <11,H;Hydroxylation;R1>
  • <12,H;Hydroxylation;R2>
  • <15,H;Hydroxylation;R3>
  • <16,H;Hydroxylation;R4>
  • <4,S;S-Oxidation;R1>
References
  1. Machinist JM, Mayer MD, Shet MS, Ferrero JL, Rodrigues AD: Identification of the human liver cytochrome P450 enzymes involved in the metabolism of zileuton (ABT-077) and its N-dehydroxylated metabolite, Abbott-66193. Drug Metab Dispos. 1995 Oct;23(10):1163-74. [PubMed:8654206 ]
Download FileCC02068.sdf