Showing CypComp Card for CC02079: 8-OH-Efavirenz (CypBoM Training Set)

Record Information
Version1.0
Creation Date2019-07-14 16:36:43 UTC
Last Updated2019-10-01 21:41:23 UTC
CypComp IDCC02079
Compound Information
Name8-OH-Efavirenz
Structure ImageOovompcqlmfedt zdusscgksa n
InChIKeyOOVOMPCQLMFEDT-ZDUSSCGKSA-N
PubChem ID487643
CypCompound Information
SetCypBoM Training Set
Bonds of Metabolism (BoMs)
CYP1A2CYP2A6CYP2B6CYP2C8CYP2C9CYP2C19CYP2D6CYP2E1CYP3A4
  • Not Available
  • <8,H;Hydroxylation;R1>
  • <8,H;Hydroxylation;R1>
  • Not Available
  • <8,H;Hydroxylation;R1>
  • <8,H;Hydroxylation;R1>
  • <8,H;Hydroxylation;R1>
  • Not Available
  • Not Available
References
  1. Ward BA, Gorski JC, Jones DR, Hall SD, Flockhart DA, Desta Z: The cytochrome P450 2B6 (CYP2B6) is the main catalyst of efavirenz primary and secondary metabolism: implication for HIV/AIDS therapy and utility of efavirenz as a substrate marker of CYP2B6 catalytic activity. J Pharmacol Exp Ther. 2003 Jul;306(1):287-300. doi: 10.1124/jpet.103.049601. Epub 2003 Apr 3. [PubMed:12676886 ]
Download FileCC02079.sdf