Showing CypComp Card for CC02100: Cisapride (CypBoM Training Set)

Record Information
Version1.0
Creation Date2019-07-14 16:36:50 UTC
Last Updated2019-10-01 21:41:26 UTC
CypComp IDCC02100
Compound Information
NameCisapride
Structure ImageDcsubabjrxzomt rbbkrzogsa n
InChIKeyDCSUBABJRXZOMT-RBBKRZOGSA-N
PubChem ID5311047
CypCompound Information
SetCypBoM Training Set
Bonds of Metabolism (BoMs)
CYP1A2CYP2A6CYP2B6CYP2C8CYP2C9CYP2C19CYP2D6CYP2E1CYP3A4
  • Not Available
  • <2,H;Hydroxylation;R1>
  • <6,H;Hydroxylation;R2>
  • <11,12;Cleavage;R1>
  • <11,H;Oxidation;R1>
  • <11,12;Cleavage;R1>
  • <11,H;Oxidation;R1>
  • <2,H;Hydroxylation;R2>
  • <6,H;Hydroxylation;R3>
  • <3,H;UnspOxidation;R4>
  • <4,7;UnspReduction;R4>
  • <4,7;UnspReduction;R5>
  • <5,H;UnspOxidation;R5>
  • Not Available
  • Not Available
  • Not Available
  • Not Available
  • <11,12;Cleavage;R1>
  • <11,H;Oxidation;R1>
  • <2,H;Hydroxylation;R2>
  • <6,H;Hydroxylation;R3>
  • <3,H;UnspOxidation;R4>
  • <4,7;UnspReduction;R4>
  • <4,7;UnspReduction;R5>
  • <5,H;UnspOxidation;R5>
References
  1. Desta Z, Soukhova N, Mahal SK, Flockhart DA: Interaction of cisapride with the human cytochrome P450 system: metabolism and inhibition studies. Drug Metab Dispos. 2000 Jul;28(7):789-800. [PubMed:10859153 ]
  2. Desta Z, Soukhova N, Morocho AM, Flockhart DA: Stereoselective metabolism of cisapride and enantiomer-enantiomer interaction in human cytochrome P450 enzymes: major role of CYP3A. J Pharmacol Exp Ther. 2001 Aug;298(2):508-20. [PubMed:11454912 ]
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