Bonds of Metabolism (BoMs) | CYP1A2 | CYP2A6 | CYP2B6 | CYP2C8 | CYP2C9 | CYP2C19 | CYP2D6 | CYP2E1 | CYP3A4 | | | - <8,H;Hydroxylation;R1>
- <6,2;Cleavage;R2>
- <6,H;Oxidation;R2>
- <7,5;Cleavage;R3>
- <7,H;Oxidation;R3>
| | | | | | - <8,H;Hydroxylation;R1>
- <6,2;Cleavage;R2>
- <6,H;Oxidation;R2>
- <7,5;Cleavage;R3>
- <7,H;Oxidation;R3>
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References | - Roy P, Yu LJ, Crespi CL, Waxman DJ: Development of a substrate-activity based approach to identify the major human liver P-450 catalysts of cyclophosphamide and ifosfamide activation based on cDNA-expressed activities and liver microsomal P-450 profiles. Drug Metab Dispos. 1999 Jun;27(6):655-66. [PubMed:10348794 ]
- Roy P, Tretyakov O, Wright J, Waxman DJ: Stereoselective metabolism of ifosfamide by human P-450s 3A4 and 2B6. Favorable metabolic properties of R-enantiomer. Drug Metab Dispos. 1999 Nov;27(11):1309-18. [PubMed:10534317 ]
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