Showing CypComp Card for CC02109: Omeprazole (CypBoM Training Set)

Record Information
Version1.0
Creation Date2019-07-14 16:36:53 UTC
Last Updated2019-10-01 21:41:28 UTC
CypComp IDCC02109
Compound Information
NameOmeprazole
Structure ImageSubdbmmjdzjvos deossopvsa n
InChIKeySUBDBMMJDZJVOS-DEOSSOPVSA-N
PubChem ID9568614
CypCompound Information
SetCypBoM Training Set
Bonds of Metabolism (BoMs)
CYP1A2CYP2A6CYP2B6CYP2C8CYP2C9CYP2C19CYP2D6CYP2E1CYP3A4
  • Not Available
  • <10,H;Hydroxylation;R1>
  • Not Available
  • <10,H;Hydroxylation;R1>
  • <10,H;Hydroxylation;R1>
  • <24,22;Cleavage;R2>
  • <24,H;Oxidation;R2>
  • <10,H;Hydroxylation;R1>
  • <24,22;Cleavage;R2>
  • <24,H;Oxidation;R2>
  • Not Available
  • Not Available
  • <12,S;S-Oxidation;R1>
  • <23,12;Reduction;R2>
  • <24,22;Cleavage;R3>
  • <24,H;Oxidation;R3>
References
  1. Abelo A, Andersson TB, Antonsson M, Naudot AK, Skanberg I, Weidolf L: Stereoselective metabolism of omeprazole by human cytochrome P450 enzymes. Drug Metab Dispos. 2000 Aug;28(8):966-72. [PubMed:10901708 ]
  2. Karam WG, Goldstein JA, Lasker JM, Ghanayem BI: Human CYP2C19 is a major omeprazole 5-hydroxylase, as demonstrated with recombinant cytochrome P450 enzymes. Drug Metab Dispos. 1996 Oct;24(10):1081-7. [PubMed:8894508 ]
Download FileCC02109.sdf