Showing CypComp Card for CC02127: Demethylsibutramine (CypBoM Training Set)

Record Information
Version1.0
Creation Date2019-07-14 16:36:59 UTC
Last Updated2019-10-01 21:41:30 UTC
CypComp IDCC02127
Compound Information
NameDemethylsibutramine
Structure ImagePlxkzklxyhlwhr hnnxbmfysa n
InChIKeyPLXKZKLXYHLWHR-HNNXBMFYSA-N
PubChem ID9838199
CypCompound Information
SetCypBoM Training Set
Bonds of Metabolism (BoMs)
CYP1A2CYP2A6CYP2B6CYP2C8CYP2C9CYP2C19CYP2D6CYP2E1CYP3A4
  • Not Available
  • Not Available
  • <13,2;Cleavage;R1>
  • <13,H;Oxidation;R1>
  • Not Available
  • Not Available
  • Not Available
  • Not Available
  • Not Available
  • Not Available
References
  1. Bae SK, Cao S, Seo KA, Kim H, Kim MJ, Shon JH, Liu KH, Zhou HH, Shin JG: Cytochrome P450 2B6 catalyzes the formation of pharmacologically active sibutramine (N-{1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutyl}-N,N-dimethylamine) metabolites in human liver microsomes. Drug Metab Dispos. 2008 Aug;36(8):1679-88. doi: 10.1124/dmd.108.020727. Epub 2008 May 12. [PubMed:18474675 ]
Download FileCC02127.sdf