Showing CypComp Card for CC02129: Dextromethorphan (CypBoM Training Set)

Record Information
Version1.0
Creation Date2019-07-14 16:36:59 UTC
Last Updated2019-10-01 21:41:30 UTC
CypComp IDCC02129
Compound Information
NameDextromethorphan
Structure ImageMkxzasyaugddcj njafhuggsa n
InChIKeyMKXZASYAUGDDCJ-NJAFHUGGSA-N
PubChem ID5360696
CypCompound Information
SetCypBoM Training Set
Bonds of Metabolism (BoMs)
CYP1A2CYP2A6CYP2B6CYP2C8CYP2C9CYP2C19CYP2D6CYP2E1CYP3A4
  • Not Available
  • Not Available
  • <18,15;Cleavage;R1>
  • <18,H;Oxidation;R1>
  • Not Available
  • <18,15;Cleavage;R1>
  • <18,H;Oxidation;R1>
  • <20,19;Cleavage;R2>
  • <20,H;Oxidation;R2>
  • <18,15;Cleavage;R1>
  • <18,H;Oxidation;R1>
  • <18,15;Cleavage;R1>
  • <18,H;Oxidation;R1>
  • <20,19;Cleavage;R2>
  • <20,H;Oxidation;R2>
  • Not Available
  • <18,15;Cleavage;R1>
  • <18,H;Oxidation;R1>
  • <20,19;Cleavage;R2>
  • <20,H;Oxidation;R2>
References
  1. Wang Y, Unadkat JD: Enzymes in addition to CYP3A4 and 3A5 mediate N-demethylation of dextromethorphan in human liver microsomes. Biopharm Drug Dispos. 1999 Oct;20(7):341-6. [PubMed:10760842 ]
  2. Flanagan JU, McLaughlin LA, Paine MJ, Sutcliffe MJ, Roberts GC, Wolf CR: Role of conserved Asp293 of cytochrome P450 2C9 in substrate recognition and catalytic activity. Biochem J. 2003 Mar 15;370(Pt 3):921-6. doi: 10.1042/BJ20021841. [PubMed:12482324 ]
  3. von Moltke LL, Greenblatt DJ, Grassi JM, Granda BW, Venkatakrishnan K, Schmider J, Harmatz JS, Shader RI: Multiple human cytochromes contribute to biotransformation of dextromethorphan in-vitro: role of CYP2C9, CYP2C19, CYP2D6, and CYP3A. J Pharm Pharmacol. 1998 Sep;50(9):997-1004. doi: 10.1111/j.2042-7158.1998.tb06914.x. [PubMed:9811160 ]
  4. Bapiro TE, Hasler JA, Ridderstrom M, Masimirembwa CM: The molecular and enzyme kinetic basis for the diminished activity of the cytochrome P450 2D6.17 (CYP2D6.17) variant. Potential implications for CYP2D6 phenotyping studies and the clinical use of CYP2D6 substrate drugs in some African populations. Biochem Pharmacol. 2002 Nov 1;64(9):1387-98. doi: 10.1016/s0006-2952(02)01351-5. [PubMed:12392820 ]
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