Showing CypComp Card for CC02131: Diclofenac (CypBoM Training Set)

Record Information
Version1.0
Creation Date2019-07-14 16:37:00 UTC
Last Updated2019-10-01 21:41:30 UTC
CypComp IDCC02131
Compound Information
NameDiclofenac
Structure ImageDcopuumxtxdbnb uhfffaoysa n
InChIKeyDCOPUUMXTXDBNB-UHFFFAOYSA-N
PubChem ID3033
CypCompound Information
SetCypBoM Training Set
Bonds of Metabolism (BoMs)
CYP1A2CYP2A6CYP2B6CYP2C8CYP2C9CYP2C19CYP2D6CYP2E1CYP3A4
  • Not Available
  • Not Available
  • <13,H;Hydroxylation;R1>
  • <13,H;Hydroxylation;R1>
  • <4,H;Hydroxylation;R2>
  • <4,H;Hydroxylation;R1>
  • <3,H;Hydroxylation;R2>
  • <5,H;Hydroxylation;R3>
  • <13,H;Hydroxylation;R1>
  • <4,H;Hydroxylation;R2>
  • Not Available
  • Not Available
  • <13,H;Hydroxylation;R1>
References
  1. Mancy A, Antignac M, Minoletti C, Dijols S, Mouries V, Duong NT, Battioni P, Dansette PM, Mansuy D: Diclofenac and its derivatives as tools for studying human cytochromes P450 active sites: particular efficiency and regioselectivity of P450 2Cs. Biochemistry. 1999 Oct 26;38(43):14264-70. doi: 10.1021/bi991195u. [PubMed:10572000 ]
  2. Tang W, Stearns RA, Wang RW, Chiu SH, Baillie TA: Roles of human hepatic cytochrome P450s 2C9 and 3A4 in the metabolic activation of diclofenac. Chem Res Toxicol. 1999 Feb;12(2):192-9. doi: 10.1021/tx9802217. [PubMed:10027798 ]
  3. Bort R, Mace K, Boobis A, Gomez-Lechon MJ, Pfeifer A, Castell J: Hepatic metabolism of diclofenac: role of human CYP in the minor oxidative pathways. Biochem Pharmacol. 1999 Sep 1;58(5):787-96. doi: 10.1016/s0006-2952(99)00167-7. [PubMed:10449188 ]
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