Showing CypComp Card for CC02140: Methadone (CypBoM Training Set)

Record Information
Version1.0
Creation Date2019-07-14 16:37:03 UTC
Last Updated2019-10-01 21:41:31 UTC
CypComp IDCC02140
Compound Information
NameMethadone
Structure ImageUssiqxcvuwkgnf qgzvfwflsa n
InChIKeyUSSIQXCVUWKGNF-QGZVFWFLSA-N
PubChem ID22267
CypCompound Information
SetCypBoM Training Set
Bonds of Metabolism (BoMs)
CYP1A2CYP2A6CYP2B6CYP2C8CYP2C9CYP2C19CYP2D6CYP2E1CYP3A4
  • Not Available
  • Not Available
  • <20,13;Cleavage;R1>
  • <20,H;Oxidation;R1>
  • <21,13;Cleavage;R2>
  • <21,H;Oxidation;R2>
  • <20,13;Cleavage;R1>
  • <20,H;Oxidation;R1>
  • <21,13;Cleavage;R2>
  • <21,H;Oxidation;R2>
  • Not Available
  • <20,13;Cleavage;R1>
  • <20,H;Oxidation;R1>
  • <21,13;Cleavage;R2>
  • <21,H;Oxidation;R2>
  • <20,13;Cleavage;R1>
  • <20,H;Oxidation;R1>
  • <21,13;Cleavage;R2>
  • <21,H;Oxidation;R2>
  • Not Available
  • <20,13;Cleavage;R1>
  • <20,H;Oxidation;R1>
  • <21,13;Cleavage;R2>
  • <21,H;Oxidation;R2>
References
  1. Iribarne C, Berthou F, Baird S, Dreano Y, Picart D, Bail JP, Beaune P, Menez JF: Involvement of cytochrome P450 3A4 enzyme in the N-demethylation of methadone in human liver microsomes. Chem Res Toxicol. 1996 Mar;9(2):365-73. doi: 10.1021/tx950116m. [PubMed:8839037 ]
  2. Gerber JG, Rhodes RJ, Gal J: Stereoselective metabolism of methadone N-demethylation by cytochrome P4502B6 and 2C19. Chirality. 2004 Jan;16(1):36-44. doi: 10.1002/chir.10303. [PubMed:14628297 ]
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