Showing CypComp Card for CC02153: Tramadol (CypBoM Training Set)

Record Information
Version1.0
Creation Date2019-07-14 16:37:07 UTC
Last Updated2019-10-01 21:41:33 UTC
CypComp IDCC02153
Compound Information
NameTramadol
Structure ImageTvyllzqtglzfbw zbfhggjfsa n
InChIKeyTVYLLZQTGLZFBW-ZBFHGGJFSA-N
PubChem ID33741
CypCompound Information
SetCypBoM Training Set
Bonds of Metabolism (BoMs)
CYP1A2CYP2A6CYP2B6CYP2C8CYP2C9CYP2C19CYP2D6CYP2E1CYP3A4
  • <18,17;Cleavage;R1>
  • <18,H;Oxidation;R1>
  • <19,17;Cleavage;R2>
  • <19,H;Oxidation;R2>
  • Not Available
  • <8,7;Cleavage;R1>
  • <8,H;Oxidation;R1>
  • <18,17;Cleavage;R2>
  • <18,H;Oxidation;R2>
  • <19,17;Cleavage;R3>
  • <19,H;Oxidation;R3>
  • Not Available
  • <18,17;Cleavage;R1>
  • <18,H;Oxidation;R1>
  • <19,17;Cleavage;R2>
  • <19,H;Oxidation;R2>
  • <18,17;Cleavage;R1>
  • <18,H;Oxidation;R1>
  • <19,17;Cleavage;R2>
  • <19,H;Oxidation;R2>
  • <8,7;Cleavage;R1>
  • <8,H;Oxidation;R1>
  • <18,17;Cleavage;R2>
  • <18,H;Oxidation;R2>
  • <19,17;Cleavage;R3>
  • <19,H;Oxidation;R3>
  • Not Available
  • <18,17;Cleavage;R1>
  • <18,H;Oxidation;R1>
  • <19,17;Cleavage;R2>
  • <19,H;Oxidation;R2>
References
  1. Zhou SF: Polymorphism of human cytochrome P450 2D6 and its clinical significance: part II. Clin Pharmacokinet. 2009;48(12):761-804. doi: 10.2165/11318070-000000000-00000. [PubMed:19902987 ]
  2. Subrahmanyam V, Renwick AB, Walters DG, Young PJ, Price RJ, Tonelli AP, Lake BG: Identification of cytochrome P-450 isoforms responsible for cis-tramadol metabolism in human liver microsomes. Drug Metab Dispos. 2001 Aug;29(8):1146-55. [PubMed:11454734 ]
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