Showing CypComp Card for CC02154: Trofosfamide (CypBoM Training Set)

Record Information
Version1.0
Creation Date2019-07-14 16:37:08 UTC
Last Updated2019-10-01 21:41:33 UTC
CypComp IDCC02154
Compound Information
NameTrofosfamide
Structure ImageUmkfepptgmdvmi qgzvfwflsa n
InChIKeyUMKFEPPTGMDVMI-QGZVFWFLSA-N
PubChem ID9576167
CypCompound Information
SetCypBoM Training Set
Bonds of Metabolism (BoMs)
CYP1A2CYP2A6CYP2B6CYP2C8CYP2C9CYP2C19CYP2D6CYP2E1CYP3A4
  • Not Available
  • <13,H;Hydroxylation;R1>
  • <12,8;Cleavage;R1>
  • <12,H;Oxidation;R1>
  • <13,H;Hydroxylation;R2>
  • Not Available
  • <13,H;Hydroxylation;R1>
  • Not Available
  • Not Available
  • Not Available
  • <2,1;Cleavage;R1>
  • <2,H;Oxidation;R1>
  • <3,1;Cleavage;R2>
  • <3,H;Oxidation;R2>
  • <12,8;Cleavage;R3>
  • <12,H;Oxidation;R3>
  • <13,H;Hydroxylation;R4>
References
  1. May-Manke A, Kroemer H, Hempel G, Bohnenstengel F, Hohenlochter B, Blaschke G, Boos J: Investigation of the major human hepatic cytochrome P450 involved in 4-hydroxylation and N-dechloroethylation of trofosfamide. Cancer Chemother Pharmacol. 1999;44(4):327-34. doi: 10.1007/s002800050985. [PubMed:10447581 ]
  2. Zhang J, Tian Q, Yung Chan S, Chuen Li S, Zhou S, Duan W, Zhu YZ: Metabolism and transport of oxazaphosphorines and the clinical implications. Drug Metab Rev. 2005;37(4):611-703. doi: 10.1080/03602530500364023. [PubMed:16393888 ]
Download FileCC02154.sdf