Showing CypComp Card for CC02161: Metoprolol (CypBoM Training Set)

Record Information
Version1.0
Creation Date2019-07-14 16:37:10 UTC
Last Updated2019-10-01 21:41:34 UTC
CypComp IDCC02161
Compound Information
NameMetoprolol
Structure ImageIubsymuccvwxpe cqszacivsa n
InChIKeyIUBSYMUCCVWXPE-CQSZACIVSA-N
PubChem ID157717
CypCompound Information
SetCypBoM Training Set
Bonds of Metabolism (BoMs)
CYP1A2CYP2A6CYP2B6CYP2C8CYP2C9CYP2C19CYP2D6CYP2E1CYP3A4
  • Not Available
  • Not Available
  • Not Available
  • Not Available
  • Not Available
  • <13,12;Cleavage;R1>
  • <13,H;Oxidation;R1>
  • <10,H;Hydroxylation;R1>
  • <19,18;Cleavage;R2>
  • <19,H;Oxidation;R2>
  • Not Available
  • <19,18;Cleavage;R1>
  • <19,H;Oxidation;R1>
References
  1. Bapiro TE, Hasler JA, Ridderstrom M, Masimirembwa CM: The molecular and enzyme kinetic basis for the diminished activity of the cytochrome P450 2D6.17 (CYP2D6.17) variant. Potential implications for CYP2D6 phenotyping studies and the clinical use of CYP2D6 substrate drugs in some African populations. Biochem Pharmacol. 2002 Nov 1;64(9):1387-98. doi: 10.1016/s0006-2952(02)01351-5. [PubMed:12392820 ]
  2. Rendic S: Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448. doi: 10.1081/DMR-120001392. [PubMed:11996015 ]
  3. Zhou SF: Polymorphism of human cytochrome P450 2D6 and its clinical significance: part II. Clin Pharmacokinet. 2009;48(12):761-804. doi: 10.2165/11318070-000000000-00000. [PubMed:19902987 ]
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