Showing CypComp Card for CC02173: delta9-Tetrahydrocannabinol (CypBoM Training Set)

Record Information
Version1.0
Creation Date2019-07-14 16:37:15 UTC
Last Updated2019-10-01 21:41:35 UTC
CypComp IDCC02173
Compound Information
Namedelta9-Tetrahydrocannabinol
Structure ImageVbglyoifklumqg uhfffaoysa n
InChIKeyVBGLYOIFKLUMQG-UHFFFAOYSA-N
PubChem ID2543
CypCompound Information
SetCypBoM Training Set
Bonds of Metabolism (BoMs)
CYP1A2CYP2A6CYP2B6CYP2C8CYP2C9CYP2C19CYP2D6CYP2E1CYP3A4
  • Not Available
  • Not Available
  • Not Available
  • Not Available
  • <17,H;Hydroxylation;R1>
  • <17,H;Hydroxylation;R1>
  • Not Available
  • Not Available
  • <4,9;EpOxidation;R1>
  • <8,H;Hydroxylation;R2>
  • <16,H;Hydroxylation;R3>
  • <17,H;Hydroxylation;R4>
References
  1. Bland TM, Haining RL, Tracy TS, Callery PS: CYP2C-catalyzed delta9-tetrahydrocannabinol metabolism: kinetics, pharmacogenetics and interaction with phenytoin. Biochem Pharmacol. 2005 Oct 1;70(7):1096-103. doi: 10.1016/j.bcp.2005.07.007. [PubMed:16112652 ]
  2. Maurer HH, Sauer C, Theobald DS: Toxicokinetics of drugs of abuse: current knowledge of the isoenzymes involved in the human metabolism of tetrahydrocannabinol, cocaine, heroin, morphine, and codeine. Ther Drug Monit. 2006 Jun;28(3):447-53. doi: 10.1097/01.ftd.0000211812.27558.6e. [PubMed:16778732 ]
  3. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
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