Showing CypComp Card for CC02179: Haloperidol (CypBoM Training Set)

Record Information
Version1.0
Creation Date2019-07-14 16:37:16 UTC
Last Updated2019-10-01 21:41:36 UTC
CypComp IDCC02179
Compound Information
NameHaloperidol
Structure ImageLnepoxffqsencj uhfffaoysa n
InChIKeyLNEPOXFFQSENCJ-UHFFFAOYSA-N
PubChem ID3559
CypCompound Information
SetCypBoM Training Set
Bonds of Metabolism (BoMs)
CYP1A2CYP2A6CYP2B6CYP2C8CYP2C9CYP2C19CYP2D6CYP2E1CYP3A4
  • Not Available
  • Not Available
  • Not Available
  • <7,6;Cleavage;R1>
  • <7,H;Oxidation;R1>
  • <7,6;Cleavage;R1>
  • <7,H;Oxidation;R1>
  • <7,6;Cleavage;R1>
  • <7,H;Oxidation;R1>
  • <7,6;Cleavage;R1>
  • <7,H;Oxidation;R1>
  • Not Available
  • <3,8;Reduction;R1>
  • <7,6;Cleavage;R2>
  • <7,H;Oxidation;R2>
  • <18,26;Reduction;R3>
References
  1. Avent KM, DeVoss JJ, Gillam EM: Cytochrome P450-mediated metabolism of haloperidol and reduced haloperidol to pyridinium metabolites. Chem Res Toxicol. 2006 Jul;19(7):914-20. doi: 10.1021/tx0600090. [PubMed:16841959 ]
  2. Fang J, McKay G, Song J, Remillrd A, Li X, Midha K: In vitro characterization of the metabolism of haloperidol using recombinant cytochrome p450 enzymes and human liver microsomes. Drug Metab Dispos. 2001 Dec;29(12):1638-43. [PubMed:11717183 ]
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