Showing CypComp Card for CC02183: Indomethacin-phenethylamide (CypBoM Training Set)

Record Information
Version1.0
Creation Date2019-07-14 16:37:17 UTC
Last Updated2019-10-01 21:41:36 UTC
CypComp IDCC02183
Compound Information
NameIndomethacin-phenethylamide
Structure ImageVydbtnadenxysn uhfffaoysa n
InChIKeyVYDBTNADENXYSN-UHFFFAOYSA-N
PubChem ID4292
CypCompound Information
SetCypBoM Training Set
Bonds of Metabolism (BoMs)
CYP1A2CYP2A6CYP2B6CYP2C8CYP2C9CYP2C19CYP2D6CYP2E1CYP3A4
  • Not Available
  • Not Available
  • Not Available
  • Not Available
  • <20,16;Cleavage;R1>
  • <20,H;Oxidation;R1>
  • <20,16;Cleavage;R1>
  • <20,H;Oxidation;R1>
  • <27,H;Hydroxylation;R2>
  • <20,16;Cleavage;R1>
  • <20,H;Oxidation;R1>
  • Not Available
  • <26,H;Hydroxylation;R1>
  • <27,H;Hydroxylation;R2>
References
  1. Remmel RP, Crews BC, Kozak KR, Kalgutkar AS, Marnett LJ: Studies on the metabolism of the novel, selective cyclooxygenase-2 inhibitor indomethacin phenethylamide in rat, mouse, and human liver microsomes: identification of active metabolites. Drug Metab Dispos. 2004 Jan;32(1):113-22. doi: 10.1124/dmd.32.1.113. [PubMed:14709628 ]
  2. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
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