Showing CypComp Card for CC02185: Licofelone (CypBoM Training Set)

Record Information
Version1.0
Creation Date2019-07-14 16:37:18 UTC
Last Updated2019-10-01 21:41:36 UTC
CypComp IDCC02185
Compound Information
NameLicofelone
Structure ImageUawxgrjvzsausz uhfffaoysa n
InChIKeyUAWXGRJVZSAUSZ-UHFFFAOYSA-N
PubChem ID133021
CypCompound Information
SetCypBoM Training Set
Bonds of Metabolism (BoMs)
CYP1A2CYP2A6CYP2B6CYP2C8CYP2C9CYP2C19CYP2D6CYP2E1CYP3A4
  • Not Available
  • Not Available
  • Not Available
  • <11,H;Hydroxylation;R1>
  • <12,H;Hydroxylation;R2>
  • <24,H;Hydroxylation;R3>
  • <25,H;Hydroxylation;R4>
  • <26,H;Hydroxylation;R5>
  • <11,H;Hydroxylation;R1>
  • <12,H;Hydroxylation;R2>
  • <24,H;Hydroxylation;R3>
  • <25,H;Hydroxylation;R4>
  • <26,H;Hydroxylation;R5>
  • <26,H;Hydroxylation;R1>
  • <26,H;Hydroxylation;R1>
  • Not Available
  • <26,H;Hydroxylation;R1>
References
  1. Albrecht W, Unger A, Nussler AK, Laufer S: In vitro metabolism of 2-[6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl] acetic acid (licofelone, ML3000), an inhibitor of cyclooxygenase-1 and -2 and 5-lipoxygenase. Drug Metab Dispos. 2008 May;36(5):894-903. doi: 10.1124/dmd.108.020347. Epub 2008 Feb 11. [PubMed:18268076 ]
  2. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
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