Showing CypComp Card for CC02191: Pioglitazone (CypBoM Training Set)

Record Information
Version1.0
Creation Date2019-07-14 16:37:20 UTC
Last Updated2019-10-01 21:41:37 UTC
CypComp IDCC02191
Compound Information
NamePioglitazone
Structure ImageHyafethfcaujay qgzvfwflsa n
InChIKeyHYAFETHFCAUJAY-QGZVFWFLSA-N
PubChem ID29010894
CypCompound Information
SetCypBoM Training Set
Bonds of Metabolism (BoMs)
CYP1A2CYP2A6CYP2B6CYP2C8CYP2C9CYP2C19CYP2D6CYP2E1CYP3A4
  • Not Available
  • Not Available
  • Not Available
  • <1,2;Cleavage;R1>
  • <2,H;Hydroxylation;R2>
  • <9,H;Hydroxylation;R3>
  • <1,H;Oxidation;R4>
  • Not Available
  • <2,H;Hydroxylation;R1>
  • Not Available
  • Not Available
  • <1,2;Cleavage;R1>
  • <2,H;Hydroxylation;R2>
  • <9,H;Hydroxylation;R3>
  • <1,H;Oxidation;R4>
References
  1. Jaakkola T, Laitila J, Neuvonen PJ, Backman JT: Pioglitazone is metabolised by CYP2C8 and CYP3A4 in vitro: potential for interactions with CYP2C8 inhibitors. Basic Clin Pharmacol Toxicol. 2006 Jul;99(1):44-51. doi: 10.1111/j.1742-7843.2006.pto_437.x. [PubMed:16867170 ]
  2. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
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