Bonds of Metabolism (BoMs) | CYP1A2 | CYP2A6 | CYP2B6 | CYP2C8 | CYP2C9 | CYP2C19 | CYP2D6 | CYP2E1 | CYP3A4 | | | | | | - <7,2;Cleavage;R1>
- <7,H;Oxidation;R1>
- <7,H;Hydroxylation;R2>
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References | - Diaz DS, Kozar MP, Smith KS, Asher CO, Sousa JC, Schiehser GA, Jacobus DP, Milhous WK, Skillman DR, Shearer TW: Role of specific cytochrome P450 isoforms in the conversion of phenoxypropoxybiguanide analogs in human liver microsomes to potent antimalarial dihydrotriazines. Drug Metab Dispos. 2008 Feb;36(2):380-5. doi: 10.1124/dmd.106.013920. Epub 2007 Nov 15. [PubMed:18006651 ]
- Arfeen M, Patel DS, Abbat S, Taxak N, Bharatam PV: Importance of cytochromes in cyclization reactions: quantum chemical study on a model reaction of proguanil to cycloguanil. J Comput Chem. 2014 Oct 30;35(28):2047-55. doi: 10.1002/jcc.23719. Epub 2014 Sep 5. [PubMed:25196060 ]
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