Showing CypComp Card for CC02196: Sildenafil (CypBoM Training Set)

Record Information
Version1.0
Creation Date2019-07-14 16:37:21 UTC
Last Updated2019-10-01 21:41:38 UTC
CypComp IDCC02196
Compound Information
NameSildenafil
Structure ImageBnrnxuuzrgqaqc uhfffaoysa n
InChIKeyBNRNXUUZRGQAQC-UHFFFAOYSA-N
PubChem ID135398744
CypCompound Information
SetCypBoM Training Set
Bonds of Metabolism (BoMs)
CYP1A2CYP2A6CYP2B6CYP2C8CYP2C9CYP2C19CYP2D6CYP2E1CYP3A4
  • Not Available
  • Not Available
  • Not Available
  • Not Available
  • <7,4;Cleavage;R1>
  • <7,H;Oxidation;R1>
  • <7,4;Cleavage;R1>
  • <7,H;Oxidation;R1>
  • <7,4;Cleavage;R1>
  • <7,H;Oxidation;R1>
  • Not Available
  • <7,4;Cleavage;R1>
  • <7,H;Oxidation;R1>
References
  1. Warrington JS, Shader RI, von Moltke LL, Greenblatt DJ: In vitro biotransformation of sildenafil (Viagra): identification of human cytochromes and potential drug interactions. Drug Metab Dispos. 2000 Apr;28(4):392-7. [PubMed:10725306 ]
  2. Hyland R, Roe EG, Jones BC, Smith DA: Identification of the cytochrome P450 enzymes involved in the N-demethylation of sildenafil. Br J Clin Pharmacol. 2001 Mar;51(3):239-48. doi: 10.1046/j.1365-2125.2001.00318.x. [PubMed:11298070 ]
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