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Record Information
Version1.0
Creation Date2019-07-14 16:37:23 UTC
Last Updated2019-10-01 21:41:38 UTC
CypComp IDCC02201
Compound Information
NameVenlafaxine
Structure ImagePnvnvhuzrojltj mrxnpfedsa n
InChIKeyPNVNVHUZROJLTJ-MRXNPFEDSA-N
PubChem ID11846746
CypCompound Information
SetCypBoM Training Set
Bonds of Metabolism (BoMs)
CYP1A2CYP2A6CYP2B6CYP2C8CYP2C9CYP2C19CYP2D6CYP2E1CYP3A4
  • Not Available
  • Not Available
  • Not Available
  • Not Available
  • <15,7;Cleavage;R1>
  • <15,H;Oxidation;R1>
  • <16,7;Cleavage;R2>
  • <16,H;Oxidation;R2>
  • <17,12;Cleavage;R3>
  • <17,H;Oxidation;R3>
  • <15,7;Cleavage;R1>
  • <15,H;Oxidation;R1>
  • <16,7;Cleavage;R2>
  • <16,H;Oxidation;R2>
  • <17,12;Cleavage;R3>
  • <17,H;Oxidation;R3>
  • <17,12;Cleavage;R1>
  • <17,H;Oxidation;R1>
  • Not Available
  • <15,7;Cleavage;R1>
  • <15,H;Oxidation;R1>
  • <16,7;Cleavage;R2>
  • <16,H;Oxidation;R2>
References
  1. Fogelman SM, Schmider J, Venkatakrishnan K, von Moltke LL, Harmatz JS, Shader RI, Greenblatt DJ: O- and N-demethylation of venlafaxine in vitro by human liver microsomes and by microsomes from cDNA-transfected cells: effect of metabolic inhibitors and SSRI antidepressants. Neuropsychopharmacology. 1999 May;20(5):480-90. doi: 10.1016/S0893-133X(98)00113-4. [PubMed:10192828 ]
  2. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
Download FileCC02201.sdf