Showing CypComp Card for CC02212: Diltiazem (CypBoM Training Set)

Record Information
Version1.0
Creation Date2019-07-14 16:37:26 UTC
Last Updated2019-10-01 21:41:40 UTC
CypComp IDCC02212
Compound Information
NameDiltiazem
Structure ImageHsugrbwqsszjop rtwawaebsa n
InChIKeyHSUGRBWQSSZJOP-RTWAWAEBSA-N
PubChem ID39186
CypCompound Information
SetCypBoM Training Set
Bonds of Metabolism (BoMs)
CYP1A2CYP2A6CYP2B6CYP2C8CYP2C9CYP2C19CYP2D6CYP2E1CYP3A4
  • Not Available
  • Not Available
  • Not Available
  • <15,14;Cleavage;R1>
  • <15,H;Oxidation;R1>
  • <16,14;Cleavage;R2>
  • <16,H;Oxidation;R2>
  • <15,14;Cleavage;R1>
  • <15,H;Oxidation;R1>
  • <16,14;Cleavage;R2>
  • <16,H;Oxidation;R2>
  • Not Available
  • <29,28;Cleavage;R1>
  • <29,H;Oxidation;R1>
  • Not Available
  • <15,14;Cleavage;R1>
  • <15,H;Oxidation;R1>
  • <16,14;Cleavage;R2>
  • <16,H;Oxidation;R2>
References
  1. Sutton D, Butler AM, Nadin L, Murray M: Role of CYP3A4 in human hepatic diltiazem N-demethylation: inhibition of CYP3A4 activity by oxidized diltiazem metabolites. J Pharmacol Exp Ther. 1997 Jul;282(1):294-300. [PubMed:9223567 ]
  2. Molden E, Asberg A, Christensen H: CYP2D6 is involved in O-demethylation of diltiazem. An in vitro study with transfected human liver cells. Eur J Clin Pharmacol. 2000 Nov;56(8):575-9. [PubMed:11151747 ]
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