Showing CypComp Card for CC02218: MK-0457 (CypBoM Training Set)

Record Information
Version1.0
Creation Date2019-07-14 16:37:28 UTC
Last Updated2019-10-01 21:41:40 UTC
CypComp IDCC02218
Compound Information
NameMK-0457
Structure ImageGcikssrwrfvxbi uhfffaoysa n
InChIKeyGCIKSSRWRFVXBI-UHFFFAOYSA-N
PubChem ID5494449
CypCompound Information
SetCypBoM Training Set
Bonds of Metabolism (BoMs)
CYP1A2CYP2A6CYP2B6CYP2C8CYP2C9CYP2C19CYP2D6CYP2E1CYP3A4
  • Not Available
  • Not Available
  • Not Available
  • <21,5;Cleavage;R1>
  • <21,H;Oxidation;R1>
  • Not Available
  • Not Available
  • Not Available
  • Not Available
  • <21,5;Cleavage;R1>
  • <21,H;Oxidation;R1>
  • <5,N;N-Oxidation;R2>
References
  1. Ballard JE, Prueksaritanont T, Tang C: Hepatic metabolism of MK-0457, a potent aurora kinase inhibitor: interspecies comparison and role of human cytochrome P450 and flavin-containing monooxygenase. Drug Metab Dispos. 2007 Sep;35(9):1447-51. doi: 10.1124/dmd.107.015438. Epub 2007 May 30. [PubMed:17537870 ]
Download FileCC02218.sdf