Bonds of Metabolism (BoMs) | CYP1A2 | CYP2A6 | CYP2B6 | CYP2C8 | CYP2C9 | CYP2C19 | CYP2D6 | CYP2E1 | CYP3A4 | | | | - <15,H;Hydroxylation;R1>
- <22,H;Hydroxylation;R1>
- <23,21;Oxidation;R2>
- <15,H;Hydroxylation;R3>
| | | | | - <15,H;Hydroxylation;R1>
- <22,H;Hydroxylation;R1>
- <23,21;Oxidation;R2>
- <15,H;Hydroxylation;R3>
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References | - Prueksaritanont T, Gorham LM, Ma B, Liu L, Yu X, Zhao JJ, Slaughter DE, Arison BH, Vyas KP: In vitro metabolism of simvastatin in humans [SBT]identification of metabolizing enzymes and effect of the drug on hepatic P450s. Drug Metab Dispos. 1997 Oct;25(10):1191-9. [PubMed:9321523 ]
- Prueksaritanont T, Ma B, Yu N: The human hepatic metabolism of simvastatin hydroxy acid is mediated primarily by CYP3A, and not CYP2D6. Br J Clin Pharmacol. 2003 Jul;56(1):120-4. doi: 10.1046/j.1365-2125.2003.01833.x. [PubMed:12848784 ]
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