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Record Information
Version1.0
Creation Date2019-07-14 16:37:30 UTC
Last Updated2019-10-01 21:41:41 UTC
CypComp IDCC02224
Compound Information
NameTienilic acid
Structure ImageAghanlsbxuwxtb uhfffaoysa n
InChIKeyAGHANLSBXUWXTB-UHFFFAOYSA-N
PubChem ID38409
CypCompound Information
SetCypBoM Training Set
Bonds of Metabolism (BoMs)
CYP1A2CYP2A6CYP2B6CYP2C8CYP2C9CYP2C19CYP2D6CYP2E1CYP3A4
  • Not Available
  • Not Available
  • Not Available
  • <13,H;Hydroxylation;R2>
  • <7,S;S-Oxidation;R1>
  • <13,H;Hydroxylation;R2>
  • <13,H;Hydroxylation;R1>
  • Not Available
  • Not Available
  • Not Available
References
  1. Jean P, Lopez-Garcia P, Dansette P, Mansuy D, Goldstein JL: Oxidation of tienilic acid by human yeast-expressed cytochromes P-450 2C8, 2C9, 2C18 and 2C19. Evidence that this drug is a mechanism-based inhibitor specific for cytochrome P-450 2C9. Eur J Biochem. 1996 Nov 1;241(3):797-804. doi: 10.1111/j.1432-1033.1996.00797.x. [PubMed:8944768 ]
  2. Lopez Garcia MP, Dansette PM, Valadon P, Amar C, Beaune PH, Guengerich FP, Mansuy D: Human-liver cytochromes P-450 expressed in yeast as tools for reactive-metabolite formation studies. Oxidative activation of tienilic acid by cytochromes P-450 2C9 and 2C10. Eur J Biochem. 1993 Apr 1;213(1):223-32. doi: 10.1111/j.1432-1033.1993.tb17752.x. [PubMed:8477697 ]
  3. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
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