Showing CypComp Card for CC02231: Bosentan (CypBoM Training Set)

Record Information
Version1.0
Creation Date2019-07-14 16:37:32 UTC
Last Updated2019-10-01 21:41:41 UTC
CypComp IDCC02231
Compound Information
NameBosentan
Structure ImageGjpicjjjrgtnod uhfffaoysa n
InChIKeyGJPICJJJRGTNOD-UHFFFAOYSA-N
PubChem ID104865
CypCompound Information
SetCypBoM Training Set
Bonds of Metabolism (BoMs)
CYP1A2CYP2A6CYP2B6CYP2C8CYP2C9CYP2C19CYP2D6CYP2E1CYP3A4
  • Not Available
  • Not Available
  • Not Available
  • Not Available
  • <21,20;Cleavage;R1>
  • <21,H;Oxidation;R1>
  • <37,H;Hydroxylation;R2>
  • <38,H;Hydroxylation;R3>
  • <39,H;Hydroxylation;R4>
  • Not Available
  • Not Available
  • Not Available
  • <21,20;Cleavage;R1>
  • <21,H;Oxidation;R1>
  • <37,H;Hydroxylation;R2>
  • <38,H;Hydroxylation;R3>
  • <39,H;Hydroxylation;R4>
References
  1. van Giersbergen PL, Treiber A, Clozel M, Bodin F, Dingemanse J: In vivo and in vitro studies exploring the pharmacokinetic interaction between bosentan, a dual endothelin receptor antagonist, and glyburide. Clin Pharmacol Ther. 2002 Apr;71(4):253-62. doi: 10.1067/mcp.2002.122473. [PubMed:11956508 ]
  2. van Giersbergen PL, Popescu G, Bodin F, Dingemanse J: Influence of mild liver impairment on the pharmacokinetics and metabolism of bosentan, a dual endothelin receptor antagonist. J Clin Pharmacol. 2003 Jan;43(1):15-22. [PubMed:12520623 ]
  3. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
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