Showing CypComp Card for CC02259: Vicriviroc (CypBoM Training Set)

Record Information
Version1.0
Creation Date2019-07-14 16:37:38 UTC
Last Updated2019-10-01 21:41:45 UTC
CypComp IDCC02259
Compound Information
NameVicriviroc
Structure ImageCnpvjjqcetwneu cyfredjksa n
InChIKeyCNPVJJQCETWNEU-CYFREDJKSA-N
PubChem ID3009355
CypCompound Information
SetCypBoM Training Set
Bonds of Metabolism (BoMs)
CYP1A2CYP2A6CYP2B6CYP2C8CYP2C9CYP2C19CYP2D6CYP2E1CYP3A4
  • Not Available
  • Not Available
  • Not Available
  • Not Available
  • <5,4;Cleavage;R1>
  • <5,4;Oxidation;R1>
  • Not Available
  • Not Available
  • Not Available
  • <5,4;Cleavage;R1>
  • <5,4;Oxidation;R1>
  • <34,N;N-Oxidation;R2>
  • <34,32;Reduction;R2>
  • <36,N;N-Oxidation;R3>
  • <2,1;Cleavage;R4>
  • <2,H;Oxidation;R4>
  • <16,1;Cleavage;R5>
  • <16,H;Oxidation;R5>
  • <18,19;Cleavage;R5>
  • <18,H;Oxidation;R5>
References
  1. Ghosal A, Ramanathan R, Yuan Y, Hapangama N, Chowdhury SK, Kishnani NS, Alton KB: Identification of human liver cytochrome P450 enzymes involved in biotransformation of vicriviroc, a CCR5 receptor antagonist. Drug Metab Dispos. 2007 Dec;35(12):2186-95. doi: 10.1124/dmd.107.017517. Epub 2007 Sep 7. [PubMed:17827338 ]
  2. Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [PubMed:19515014 ]
Download FileCC02259.sdf