Showing CypComp Card for CC02274: Codeine (CypBoM Training Set)

Record Information
Version1.0
Creation Date2019-07-14 16:37:42 UTC
Last Updated2019-10-01 21:41:46 UTC
CypComp IDCC02274
Compound Information
NameCodeine
Structure ImageOrogseyttfocan dnjotxnnsa n
InChIKeyOROGSEYTTFOCAN-DNJOTXNNSA-N
PubChem ID5284371
CypCompound Information
SetCypBoM Training Set
Bonds of Metabolism (BoMs)
CYP1A2CYP2A6CYP2B6CYP2C8CYP2C9CYP2C19CYP2D6CYP2E1CYP3A4
  • Not Available
  • Not Available
  • Not Available
  • Not Available
  • Not Available
  • Not Available
  • <22,15;Cleavage;R1>
  • <22,H;Oxidation;R1>
  • Not Available
  • <21,18;Cleavage;R1>
  • <21,H;Oxidation;R1>
References
  1. Caraco Y, Tateishi T, Guengerich FP, Wood AJ: Microsomal codeine N-demethylation: cosegregation with cytochrome P4503A4 activity. Drug Metab Dispos. 1996 Jul;24(7):761-4. [PubMed:8818573 ]
  2. Venhorst J, ter Laak AM, Commandeur JN, Funae Y, Hiroi T, Vermeulen NP: Homology modeling of rat and human cytochrome P450 2D (CYP2D) isoforms and computational rationalization of experimental ligand-binding specificities. J Med Chem. 2003 Jan 2;46(1):74-86. doi: 10.1021/jm0209578. [PubMed:12502361 ]
Download FileCC02274.sdf