Showing CypComp Card for CC02276: Debrisoquine (CypBoM Training Set)

Record Information
Version1.0
Creation Date2019-07-14 16:37:42 UTC
Last Updated2019-10-01 21:41:47 UTC
CypComp IDCC02276
Compound Information
NameDebrisoquine
Structure ImageJwpgjsvjdajrlw uhfffaoysa n
InChIKeyJWPGJSVJDAJRLW-UHFFFAOYSA-N
PubChem ID2966
CypCompound Information
SetCypBoM Training Set
Bonds of Metabolism (BoMs)
CYP1A2CYP2A6CYP2B6CYP2C8CYP2C9CYP2C19CYP2D6CYP2E1CYP3A4
  • Not Available
  • Not Available
  • Not Available
  • Not Available
  • Not Available
  • Not Available
  • <3,H;Hydroxylation;R1>
  • <5,H;Hydroxylation;R2>
  • <9,H;Hydroxylation;R3>
  • Not Available
  • Not Available
References
  1. Bapiro TE, Hasler JA, Ridderstrom M, Masimirembwa CM: The molecular and enzyme kinetic basis for the diminished activity of the cytochrome P450 2D6.17 (CYP2D6.17) variant. Potential implications for CYP2D6 phenotyping studies and the clinical use of CYP2D6 substrate drugs in some African populations. Biochem Pharmacol. 2002 Nov 1;64(9):1387-98. doi: 10.1016/s0006-2952(02)01351-5. [PubMed:12392820 ]
  2. Eiermann B, Edlund PO, Tjernberg A, Dalen P, Dahl ML, Bertilsson L: 1- and 3-hydroxylations, in addition to 4-hydroxylation, of debrisoquine are catalyzed by cytochrome P450 2D6 in humans. Drug Metab Dispos. 1998 Nov;26(11):1096-101. [PubMed:9806952 ]
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