Showing CypComp Card for CC02285: Gepirone (CypBoM Training Set)

Record Information
Version1.0
Creation Date2019-07-14 16:37:45 UTC
Last Updated2019-10-01 21:41:48 UTC
CypComp IDCC02285
Compound Information
NameGepirone
Structure ImageQoigkgmmagjznz uhfffaoysa n
InChIKeyQOIGKGMMAGJZNZ-UHFFFAOYSA-N
PubChem ID55191
CypCompound Information
SetCypBoM Training Set
Bonds of Metabolism (BoMs)
CYP1A2CYP2A6CYP2B6CYP2C8CYP2C9CYP2C19CYP2D6CYP2E1CYP3A4
  • Not Available
  • Not Available
  • Not Available
  • Not Available
  • Not Available
  • Not Available
  • <20,H;Hydroxylation;R1>
  • <22,H;Hydroxylation;R2>
  • <12,H;Hydroxylation;R3>
  • Not Available
  • <12,H;Hydroxylation;R1>
  • <20,H;Hydroxylation;R2>
  • <22,H;Hydroxylation;R3>
  • <13,11;Cleavage;R4>
  • <13,H;Oxidation;R4>
References
  1. Mathew SJ, Garakani A, Reinhard JF Jr, Oshana S, Donahue S: Short-term tolerability of a nonazapirone selective serotonin 1A agonist in adults with generalized anxiety disorder: a 28-day, open-label study. Clin Ther. 2008 Sep;30(9):1658-66. doi: 10.1016/j.clinthera.2008.09.006. [PubMed:18840371 ]
  2. von Moltke LL, Greenblatt DJ, Grassi JM, Granda BW, Fogelman SM, Harmatz JS, Kramer SJ, Fabre LF, Shader RI: Gepirone and 1-(2-pyrimidinyl)-piperazine in vitro: human cytochromes mediating transformation and cytochrome inhibitory effects. Psychopharmacology (Berl). 1998 Dec;140(3):293-9. [PubMed:9877009 ]
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