Showing CypComp Card for CC02306: 4-Demethylolanzapine (CypBoM Training Set)

Record Information
Version1.0
Creation Date2019-07-14 16:37:50 UTC
Last Updated2019-10-01 21:41:50 UTC
CypComp IDCC02306
Compound Information
Name4-Demethylolanzapine
Structure ImageFhpixvhjeizkjw uhfffaoysa n
InChIKeyFHPIXVHJEIZKJW-UHFFFAOYSA-N
PubChem ID135446209
CypCompound Information
SetCypBoM Training Set
Bonds of Metabolism (BoMs)
CYP1A2CYP2A6CYP2B6CYP2C8CYP2C9CYP2C19CYP2D6CYP2E1CYP3A4
  • <15,H;Hydroxylation;R1>
  • Not Available
  • Not Available
  • Not Available
  • Not Available
  • Not Available
  • <15,H;Hydroxylation;R1>
  • Not Available
  • Not Available
References
  1. Ring BJ, Catlow J, Lindsay TJ, Gillespie T, Roskos LK, Cerimele BJ, Swanson SP, Hamman MA, Wrighton SA: Identification of the human cytochromes P450 responsible for the in vitro formation of the major oxidative metabolites of the antipsychotic agent olanzapine. J Pharmacol Exp Ther. 1996 Feb;276(2):658-66. [PubMed:8632334 ]
  2. Kassahun K, Mattiuz E, Nyhart E Jr, Obermeyer B, Gillespie T, Murphy A, Goodwin RM, Tupper D, Callaghan JT, Lemberger L: Disposition and biotransformation of the antipsychotic agent olanzapine in humans. Drug Metab Dispos. 1997 Jan;25(1):81-93. [PubMed:9010634 ]
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