Bonds of Metabolism (BoMs) | CYP1A2 | CYP2A6 | CYP2B6 | CYP2C8 | CYP2C9 | CYP2C19 | CYP2D6 | CYP2E1 | CYP3A4 | | | | | | | | - <1,2;Oxidation;R1>
- <1,5;Reduction;R1>
- <2,3;Reduction;R1>
- <3,4;Cleavage;R1>
- <3,H;Oxidation;R1>
- <5,4;Oxidation;R1>
- <1,2;Oxidation;R2>
- <1,5;Reduction;R2>
- <2,3;Reduction;R2>
- <5,4;Cleavage;R2>
- <5,H;Oxidation;R2>
- <3,4;Oxidation;R2>
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References | - Kedderis GL, Carfagna MA, Held SD, Batra R, Murphy JE, Gargas ML: Kinetic analysis of furan biotransformation by F-344 rats in vivo and in vitro. Toxicol Appl Pharmacol. 1993 Dec;123(2):274-82. doi: 10.1006/taap.1993.1246. [PubMed:8248934 ]
- Lu D, Peterson LA: Identification of furan metabolites derived from cysteine-cis-2-butene-1,4-dial-lysine cross-links. Chem Res Toxicol. 2010 Jan;23(1):142-51. doi: 10.1021/tx9003215. [PubMed:20043645 ]
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