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Record Information
Version1.0
Creation Date2019-07-14 16:38:00 UTC
Last Updated2019-10-01 21:41:55 UTC
CypComp IDCC02343
Compound Information
Name4-Hydroxytamoxifen
Structure ImageTxuzvzsfrxzgtl qplcgjkrsa n
InChIKeyTXUZVZSFRXZGTL-QPLCGJKRSA-N
PubChem ID449459
CypCompound Information
SetCypBoM Training Set
Bonds of Metabolism (BoMs)
CYP1A2CYP2A6CYP2B6CYP2C8CYP2C9CYP2C19CYP2D6CYP2E1CYP3A4
  • Not Available
  • Not Available
  • Not Available
  • Not Available
  • Not Available
  • Not Available
  • Not Available
  • Not Available
  • <16,H;Hydroxylation;R1>
  • <17,H;Hydroxylation;R2>
References
  1. Dehal SS, Kupfer D: Cytochrome P-450 3A and 2D6 catalyze ortho hydroxylation of 4-hydroxytamoxifen and 3-hydroxytamoxifen (droloxifene) yielding tamoxifen catechol: involvement of catechols in covalent binding to hepatic proteins. Drug Metab Dispos. 1999 Jun;27(6):681-8. [PubMed:10348797 ]
Download FileCC02343.sdf