Bonds of Metabolism (BoMs) | CYP1A2 | CYP2A6 | CYP2B6 | CYP2C8 | CYP2C9 | CYP2C19 | CYP2D6 | CYP2E1 | CYP3A4 | | | | | | | | | - <13,H;Hydroxylation;R1>
- <9,H;Hydroxylation;R2>
- <6,H;Hydroxylation;R3>
- <12,5;Cleavage;R4>
- <12,H;Oxidation;R4>
- <25,H;Hydroxylation;R5>
- <19,16;Cleavage;R6>
- <19,H;Oxidation;R6>
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References | - Tuvesson H, Hallin I, Persson R, Sparre B, Gunnarsson PO, Seidegard J: Cytochrome P450 3A4 is the major enzyme responsible for the metabolism of laquinimod, a novel immunomodulator. Drug Metab Dispos. 2005 Jun;33(6):866-72. doi: 10.1124/dmd.104.002238. Epub 2005 Mar 11. [PubMed:15764719 ]
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