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Record Information
Version1.0
Creation Date2019-07-14 16:55:05 UTC
Last Updated2019-10-01 21:42:08 UTC
CypComp IDCC02435
Compound Information
NameQuinacrine
Structure ImageGpkjtrjobqgkqk mrxnpfedsa n
InChIKeyGPKJTRJOBQGKQK-MRXNPFEDSA-N
PubChem ID446536
CypCompound Information
SetCypBoM Training Set
Bonds of Metabolism (BoMs)
CYP1A2CYP2A6CYP2B6CYP2C8CYP2C9CYP2C19CYP2D6CYP2E1CYP3A4
  • <24,19;Cleavage;R1>
  • <24,H;Oxidation;R1>
  • <23,19;Cleavage;R2>
  • <23,H;Oxidation;R2>
  • Not Available
  • <24,19;Cleavage;R1>
  • <24,H;Oxidation;R1>
  • <23,19;Cleavage;R2>
  • <23,H;Oxidation;R2>
  • <24,19;Cleavage;R1>
  • <24,H;Oxidation;R1>
  • <23,19;Cleavage;R2>
  • <23,H;Oxidation;R2>
  • Not Available
  • <24,19;Cleavage;R1>
  • <24,H;Oxidation;R1>
  • <23,19;Cleavage;R2>
  • <23,H;Oxidation;R2>
  • <24,19;Cleavage;R1>
  • <24,H;Oxidation;R1>
  • <23,19;Cleavage;R2>
  • <23,H;Oxidation;R2>
  • Not Available
  • <24,19;Cleavage;R1>
  • <24,H;Oxidation;R1>
  • <23,19;Cleavage;R2>
  • <23,H;Oxidation;R2>
References
  1. Huang Y, Okochi H, May BC, Legname G, Prusiner SB, Benet LZ, Guglielmo BJ, Lin ET: Quinacrine is mainly metabolized to mono-desethyl quinacrine by CYP3A4/5 and its brain accumulation is limited by P-glycoprotein. Drug Metab Dispos. 2006 Jul;34(7):1136-44. doi: 10.1124/dmd.105.008664. Epub 2006 Mar 31. [PubMed:16581945 ]
Download FileCC02435.sdf