Showing CypComp Card for CC02451: Sirolimus (CypBoM Training Set)

Record Information
Version1.0
Creation Date2019-07-14 16:55:10 UTC
Last Updated2019-10-01 21:42:10 UTC
CypComp IDCC02451
Compound Information
NameSirolimus
Structure ImageQfjcirlumzquot hpljoqbzsa n
InChIKeyQFJCIRLUMZQUOT-HPLJOQBZSA-N
PubChem ID5284616
CypCompound Information
SetCypBoM Training Set
Bonds of Metabolism (BoMs)
CYP1A2CYP2A6CYP2B6CYP2C8CYP2C9CYP2C19CYP2D6CYP2E1CYP3A4
  • Not Available
  • Not Available
  • Not Available
  • Not Available
  • Not Available
  • Not Available
  • Not Available
  • Not Available
  • <44,38;Cleavage;R1>
  • <44,H;Oxidation;R1>
  • <51,46;Cleavage;R2>
  • <51,H;Oxidation;R2>
  • <63,H;Hydroxylation;R3>
  • <62,H;Hydroxylation;R4>
  • <58,H;Hydroxylation;R5>
  • <22,H;Hydroxylation;R6>
  • <17,H;Hydroxylation;R7>
References
  1. Cummins CL, Jacobsen W, Christians U, Benet LZ: CYP3A4-transfected Caco-2 cells as a tool for understanding biochemical absorption barriers: studies with sirolimus and midazolam. J Pharmacol Exp Ther. 2004 Jan;308(1):143-55. doi: 10.1124/jpet.103.058065. Epub 2003 Oct 20. [PubMed:14569063 ]
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