Showing CypComp Card for CC02463: Zafirlukast (CypBoM Training Set)

Record Information
Version1.0
Creation Date2019-07-14 16:55:13 UTC
Last Updated2019-10-01 21:42:12 UTC
CypComp IDCC02463
Compound Information
NameZafirlukast
Structure ImageYeezwchgznkeek uhfffaoysa n
InChIKeyYEEZWCHGZNKEEK-UHFFFAOYSA-N
PubChem ID5717
CypCompound Information
SetCypBoM Training Set
Bonds of Metabolism (BoMs)
CYP1A2CYP2A6CYP2B6CYP2C8CYP2C9CYP2C19CYP2D6CYP2E1CYP3A4
  • Not Available
  • Not Available
  • Not Available
  • Not Available
  • Not Available
  • Not Available
  • Not Available
  • Not Available
  • <11,H;Hydroxylation;R1>
  • <29,H;Hydroxylation;R2>
References
  1. Kassahun K, Skordos K, McIntosh I, Slaughter D, Doss GA, Baillie TA, Yost GS: Zafirlukast metabolism by cytochrome P450 3A4 produces an electrophilic alpha,beta-unsaturated iminium species that results in the selective mechanism-based inactivation of the enzyme. Chem Res Toxicol. 2005 Sep;18(9):1427-37. doi: 10.1021/tx050092b. [PubMed:16167835 ]
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