Showing CypComp Card for CC02472: BMS-275183 (CypBoM Training Set)

Record Information
Version1.0
Creation Date2019-07-14 16:55:15 UTC
Last Updated2019-10-01 21:42:13 UTC
CypComp IDCC02472
Compound Information
NameBMS-275183
Structure ImageAhxichppxigcbn tyvwmptdsa n
InChIKeyAHXICHPPXIGCBN-TYVWMPTDSA-N
PubChem IDNot Available
CypCompound Information
SetCypBoM Training Set
Bonds of Metabolism (BoMs)
CYP1A2CYP2A6CYP2B6CYP2C8CYP2C9CYP2C19CYP2D6CYP2E1CYP3A4
  • Not Available
  • Not Available
  • Not Available
  • Not Available
  • Not Available
  • Not Available
  • Not Available
  • Not Available
  • <55,H;Hydroxylation;R1>
  • <53,H;Hydroxylation;R2>
  • <54,H;Hydroxylation;R3>
  • <58,H;Hydroxylation;R4>
  • <59,H;Hydroxylation;R5>
  • <60,H;Hydroxylation;R6>
References
  1. Zhang D, Ly VT, Lago M, Tian Y, Gan J, Humphreys WG, Comezoglu SN: CYP3A4-mediated ester cleavage as the major metabolic pathway of the oral taxane 3'-tert-butyl-3'-N-tert-butyloxycarbonyl-4-deacetyl-3'-dephenyl-3'-N-debenzoyl-4- O-methoxycarbonyl-paclitaxel (BMS-275183). Drug Metab Dispos. 2009 Apr;37(4):710-8. doi: 10.1124/dmd.108.024398. Epub 2009 Jan 21. [PubMed:19158314 ]
Download FileCC02472.sdf