Showing CypComp Card for CC02481: Promethazine (CypBoM Testing Set)

Record Information
Version1.0
Creation Date2019-07-14 16:55:18 UTC
Last Updated2019-10-01 21:42:14 UTC
CypComp IDCC02481
Compound Information
NamePromethazine
Structure ImagePwwvaxiegoywee uhfffaoysa n
InChIKeyPWWVAXIEGOYWEE-UHFFFAOYSA-N
PubChem ID4927
CypCompound Information
SetCypBoM Testing Set
Bonds of Metabolism (BoMs)
CYP1A2CYP2A6CYP2B6CYP2C8CYP2C9CYP2C19CYP2D6CYP2E1CYP3A4
  • Not Available
  • Not Available
  • Not Available
  • Not Available
  • Not Available
  • Not Available
  • <19,18;Cleavage;R1>
  • <19,H;Oxidation;R1>
  • <20,18;Cleavage;R2>
  • <20,H;Oxidation;R2>
  • <11,S;S-Oxidation;R3>
  • Not Available
  • Not Available
References
  1. Rudik AV, Dmitriev AV, Lagunin AA, Filimonov DA, Poroikov VV: Prediction of reacting atoms for the major biotransformation reactions of organic xenobiotics. J Cheminform. 2016 Nov 28;8:68. doi: 10.1186/s13321-016-0183-x. eCollection 2016. [PubMed:27994650 ]
  2. Nakamura K, Yokoi T, Inoue K, Shimada N, Ohashi N, Kume T, Kamataki T: CYP2D6 is the principal cytochrome P450 responsible for metabolism of the histamine H1 antagonist promethazine in human liver microsomes. Pharmacogenetics. 1996 Oct;6(5):449-57. [PubMed:8946477 ]
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