Showing CypComp Card for CC02531: Nisoldipine (CypBoM Testing Set)

Record Information
Version1.0
Creation Date2019-07-14 16:55:37 UTC
Last Updated2019-10-01 21:42:21 UTC
CypComp IDCC02531
Compound Information
NameNisoldipine
Structure ImageVkqfcgnpdricfg uhfffaoysa n
InChIKeyVKQFCGNPDRICFG-UHFFFAOYSA-N
PubChem ID4499
CypCompound Information
SetCypBoM Testing Set
Bonds of Metabolism (BoMs)
CYP1A2CYP2A6CYP2B6CYP2C8CYP2C9CYP2C19CYP2D6CYP2E1CYP3A4
  • <7,2;Oxidation;R1>
  • <2,3;Reduction;R1>
  • <3,4;Oxidation;R1>
  • <4,5;Oxidation;R1>
  • <5,6;Reduction;R1>
  • <6,7;Oxidation;R1>
  • Not Available
  • Not Available
  • Not Available
  • <7,2;Oxidation;R1>
  • <2,3;Reduction;R1>
  • <3,4;Oxidation;R1>
  • <4,5;Oxidation;R1>
  • <5,6;Reduction;R1>
  • <6,7;Oxidation;R1>
  • <7,2;Oxidation;R1>
  • <2,3;Reduction;R1>
  • <3,4;Oxidation;R1>
  • <4,5;Oxidation;R1>
  • <5,6;Reduction;R1>
  • <6,7;Oxidation;R1>
  • <7,2;Oxidation;R1>
  • <2,3;Reduction;R1>
  • <3,4;Oxidation;R1>
  • <4,5;Oxidation;R1>
  • <5,6;Reduction;R1>
  • <6,7;Oxidation;R1>
  • <7,2;Oxidation;R1>
  • <2,3;Reduction;R1>
  • <3,4;Oxidation;R1>
  • <4,5;Oxidation;R1>
  • <5,6;Reduction;R1>
  • <6,7;Oxidation;R1>
  • <7,2;Oxidation;R1>
  • <2,3;Reduction;R1>
  • <3,4;Oxidation;R1>
  • <4,5;Oxidation;R1>
  • <5,6;Reduction;R1>
  • <6,7;Oxidation;R1>
References
  1. Komura H, Yasuda M, Yoshida NH, Sugiyama Y: Species difference in nisoldipine oxidation activity in the small intestine. Drug Metab Pharmacokinet. 2002;17(5):427-36. [PubMed:15618694 ]
  2. Yuan L, Jia P, Sun Y, Zhao C, Zhi X, Sheng N, Zhang L: Study of in vitro metabolism of m-nisoldipine in human liver microsomes and recombinant cytochrome P450 enzymes by liquid chromatography-mass spectrometry. J Pharm Biomed Anal. 2014 Aug;97:65-71. doi: 10.1016/j.jpba.2014.03.030. Epub 2014 Mar 28. [PubMed:24816159 ]
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