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Showing CypComp Card for CC02537: Letrozole (CypBoM Testing Set)

Record Information
Version1.0
Creation Date2019-07-14 16:55:41 UTC
Last Updated2019-10-01 21:42:22 UTC
CypComp IDCC02537
Compound Information
NameLetrozole
Structure ImageHpjkciuczwxjdr uhfffaoysa n
InChIKeyHPJKCIUCZWXJDR-UHFFFAOYSA-N
PubChem ID3902
CypCompound Information
SetCypBoM Testing Set
Bonds of Metabolism (BoMs)
CYP1A2CYP2A6CYP2B6CYP2C8CYP2C9CYP2C19CYP2D6CYP2E1CYP3A4
  • Not Available
  • <6,1;Cleavage;R1>
  • <6,H;Oxidation;R1>
  • Not Available
  • Not Available
  • Not Available
  • Not Available
  • Not Available
  • Not Available
  • <6,1;Cleavage;R1>
  • <6,H;Oxidation;R1>
References
  1. Jeong S, Woo MM, Flockhart DA, Desta Z: Inhibition of drug metabolizing cytochrome P450s by the aromatase inhibitor drug letrozole and its major oxidative metabolite 4,4'-methanol-bisbenzonitrile in vitro. Cancer Chemother Pharmacol. 2009 Oct;64(5):867-75. doi: 10.1007/s00280-009-0935-7. Epub 2009 Feb 7. [PubMed:19198839 ]
  2. Desta Z, Ward BA, Flockhart DA: In vitro letrozole N-dealkylation is mainly catalyzed by human cytochrome P450 (CYP) 3A Clin Pharmacol Ther. 2005 Feb 01;77(2):79. doi: 10.1016/j.clpt.2004.12.193.
Download FileCC02537.sdf